Gene DEF8

All Male only Female only
Location (GRCh37):
chr16:90,014,333-90,034,468
Description:
differentially expressed in FDCP 8 homolog (mouse) [Source:HGNC Symbol;Acc:25969]
Biotype
Protein coding
Nb components:
21
Ensembl:
ENSG00000140995
HGNC Symbol:
25969
Uniprot:
Q6ZN54, H3BMP4, H3BT01, H3BQ81, H3BTS7, H3BRA7, H3BMT5, H3BNN0, H3BSH6, H3BQH5, H3BQX9, H3BT87
WikiGene:
54849
Median gene-level TPM by tissue (GTEx) [link]:

This plot shows tissues where the current gene is most expressed in GTEx to help contextualize phenotype associations.

Genetic associations QQ-plot

Inflation factor 𝜆=

This plot shows the distribution of observed association P-values compared to the expected distribution under the null hypothesis of no association (uniform distribution of P-values). Systematic deviation from the shaded region indicates statistical inflation that could be explained by pleiotropy.

Continuous variables

Outcome Id Description N -log10(P) P-Value P-Value (Bonferroni) Q-Value

* Values noted as 0 represent values smaller than the numerical floating point representation limit (< 2e-308 for this analysis).

Cardiovascular Endpoints

Outcome Id Description N cases N controls N excluded from controls -log10(P) P-Value P-Value (Bonferroni) Q-Value

Self Reported

Outcome Id Description N cases N controls N excluded from controls -log10(P) P-Value P-Value (Bonferroni) Q-Value

Phecodes

Outcome Id Description N cases N controls N excluded from controls -log10(P) P-Value P-Value (Bonferroni) Q-Value